Rescue from failed growth factor and/or chemotherapy HSC mobilization with G-CSF and plerixafor (AMD3100): an institutional experience

@article{Fowler2009RescueFF,
  title={Rescue from failed growth factor and/or chemotherapy HSC mobilization with G-CSF and plerixafor (AMD3100): an institutional experience},
  author={Clare Juliet Fowler and Annabel Dunn and BM Hayes-Lattin and Kristine Hansen and Louise O Hansen and Katherine L. Lanier and Vincy Nelson and T. Kovacsovics and J P Leis and Gary Calandra and Richard T Maziarz},
  journal={Bone Marrow Transplantation},
  year={2009},
  volume={43},
  pages={909-917}
}
Auto-SCT has been shown to be a potentially curative treatment for a variety of hematological malignancies. Auto-SCT is dependent on the successful mobilization and collection of hematopoietic stem cells to ensure engraftment. The inability to mobilize sufficient number of hematopoietic stem cells using standard cytokine-assisted mobilization strategies excludes eligible patients from potentially curative auto-SCT. Plerixafor (AMD3100; Mozobil), a novel bicyclam antagonist of the SDF-1α/CXCR4… CONTINUE READING

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Role of CXR4

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