Rescue and regeneration of injured peripheral nerve axons by intrathecal insulin.

@article{Toth2006RescueAR,
  title={Rescue and regeneration of injured peripheral nerve axons by intrathecal insulin.},
  author={Cory C Toth and Valentine Brussee and J Alfredo Mart{\'i}nez and David McDonald and F Alexander Cunningham and Douglas W Zochodne},
  journal={Neuroscience},
  year={2006},
  volume={139 2},
  pages={429-49}
}
Insulin peptide, acting through tyrosine kinase receptor pathways, contributes to nerve development or repair. In this work, we examined the direction, impact and repertoire of insulin signaling in vivo during peripheral nerve regeneration in rats. First, we demonstrated that insulin receptor is expressed on lumbar dorsal root ganglia neuronal perikarya using immunohistochemistry. Immunoblots and polymerase chain reactions confirmed the presence of both alpha and beta insulin receptor subunits… CONTINUE READING

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