Rescue Treatment with a Rho-Kinase Inhibitor Normalizes 1 Right-Ventricular Function and Reverses Remodeling in 2 Juvenile Rats with Chronic Pulmonary Hypertension

Abstract

22 23 Chronic pulmonary hypertension in infancy and childhood is characterized by a fixed and 24 progressive increase in pulmonary arterial pressure and resistance, pulmonary arterial remodeling 25 and right-ventricular hypertrophy and systolic dysfunction. These abnormalities are replicated in 26 neonatal rats chronically exposed to hypoxia from birth in… (More)

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