ResT, a telomere resolvase encoded by the Lyme disease spirochete.

@article{Kobryn2002ResTAT,
  title={ResT, a telomere resolvase encoded by the Lyme disease spirochete.},
  author={Kerri Kobryn and George Chaconas},
  journal={Molecular cell},
  year={2002},
  volume={9 1},
  pages={
          195-201
        }
}
The genus Borrelia includes the causative agents of Lyme disease and relapsing fever. An unusual feature of these bacteria is a segmented genome consisting mostly of a number of linear DNA molecules with covalently closed hairpin ends or telomeres. In this study we show that the BBB03 locus encodes the B. burgdorferi telomere resolvase, ResT. The purified protein catalyzes telomere resolution in vitro through a unique reaction: breakage of two phosphodiester bonds in a single DNA duplex (one on… CONTINUE READING
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