Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions.

@article{Gu2012RequirementsOT,
  title={Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions.},
  author={Ai-di Gu and Yunqi Wang and Lin Lin and Song Zhang and Yisong Y. Wan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 3},
  pages={905-10}
}
TGF-β modulates immune response by suppressing non-regulatory T (Treg) function and promoting Treg function. The question of whether TGF-β achieves distinct effects on non-Treg and Treg cells through discrete signaling pathways remains outstanding. In this study, we investigated the requirements of Smad-dependent and -independent TGF-β signaling for T-cell function. Smad2 and Smad3 double deficiency in T cells led to lethal inflammatory disorder in mice. Non-Treg cells were spontaneously… CONTINUE READING

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Stability of the regulatory T cell lineage in vivo

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