Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1.

@article{Lopez2001RequirementsFT,
  title={Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1.},
  author={Pascal Lopez and Charles Van Sant and Bernard Roizman},
  journal={Journal of virology},
  year={2001},
  volume={75 8},
  pages={3832-40}
}
Earlier studies have shown that wild-type infected-cell protein 0 (ICP0), a key herpes simplex virus regulatory protein, translocates from the nucleus to the cytoplasm of human embryonic lung (HEL) fibroblasts within several hours after infection (Y. Kawaguchi, R. Bruni, and B. Roizman, J. Virol. 71:1019-1024, 1997). Translocation of ICP0 was also observed in cells infected with the d120 mutant, in which both copies of the gene encoding ICP4, the major regulatory protein, had been deleted (V… CONTINUE READING
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Herpes simplex virus 1 a regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3

Y. Kawaguchi, C. Van Sant, B. Roizman
J. Virol • 1997

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