Requirements for proximal tubule epithelial cell detachment in response to ischemia: role of oxidative stress.

@article{SenzMorales2006RequirementsFP,
  title={Requirements for proximal tubule epithelial cell detachment in response to ischemia: role of oxidative stress.},
  author={David S{\'a}enz-Morales and Maria M Escribese and Konstantinos Stamatakis and Mar{\'i}a Garc{\'i}a-Martos and Laura Moles Alegre and Elisa Conde and Dolores P{\'e}rez-Sala and Francisco M. Mampaso and Mar{\'i}a Laura Garc{\'i}a-Bermejo},
  journal={Experimental cell research},
  year={2006},
  volume={312 19},
  pages={
          3711-27
        }
}
Sublethal renal ischemia induces tubular epithelium damage and kidney dysfunction. Using NRK-52E rat proximal tubular epithelial cells, we have established an in vitro model, which includes oxygen and nutrients deprivation, to study the proximal epithelial cell response to ischemia. By means of this system, we demonstrate that confluent NRK-52E cells lose monolayer integrity and detach from collagen IV due to: (i) actin cytoskeleton reorganization; (ii) Rac1 and RhoA activity alterations; (iii… CONTINUE READING
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