Requirements for peptide binding to the human transporter associated with antigen processing revealed by peptide scans and complex peptide libraries.

@article{Uebel1995RequirementsFP,
  title={Requirements for peptide binding to the human transporter associated with antigen processing revealed by peptide scans and complex peptide libraries.},
  author={S Uebel and Troels Meyer and Wolfgang Kraas and Stefan Kienle and Guenther Jung and K H Wiesm{\"u}ller and Robert Tamp{\'e}},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 31},
  pages={18512-6}
}
Antigenic peptides are translocated into the lumen of the endoplasmic reticulum by the action of the transporter associated with antigen processing (TAP), where they are subsequently needed for the correct assembly of major histocompatibility complex molecules. The transport function was reconstituted in insect cells by expression of both TAP genes. On the basis of this over-expression system, substrate selection was analyzed in detail by a direct biomolecular peptide binding assay. Competition… CONTINUE READING

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