Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosine.

  title={Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosine.},
  author={Barboros Balabanli and Yoshinori Kamisaki and Emil Martin and Ferid Murad},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 23},
Peroxynitrite-dependent formation of nitrotyrosine has been associated with inactivation of various enzymes and proteins possessing functionally important tyrosines. We have previously reported an enzymatic activity modifying the nitrotyrosine residues in nitrated proteins. Here we are describing a nonenzymatic reduction of nitrotyrosine to aminotyrosine, which depends on heme and thiols. Various heme-containing proteins can mediate the reaction, although the reaction also is catalyzed by heme… CONTINUE READING

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