Requirements for apoptotic cell contact in regulation of macrophage responses.

  title={Requirements for apoptotic cell contact in regulation of macrophage responses.},
  author={M Lee Lucas and Lynda M Stuart and Ailiang Zhang and Kairbaan M Hodivala-Dilke and Maria Febbraio and Roy Silverstein and John Savill and Adam Lacy-Hulbert},
  journal={Journal of immunology},
  volume={177 6},
An important consequence of macrophage engulfment of apoptotic cells is suppression of inflammatory responses, which was first defined by assay of TNF-alpha release stimulated by LPS. These effects are apparently mediated in part by paracrine effects of TGF-beta released by the subset of stimulated macrophages that ingest apoptotic cells, which suppresses neighboring cells. However, the apoptotic cell-derived signal that stimulates TGF-beta release, and the nature of any additional signals… CONTINUE READING

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