Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing

@inproceedings{Beaghton2017RequirementsFD,
  title={Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing},
  author={Andrea K Beaghton and Andrew M Hammond and Tony Nolan and Andrea Crisanti and H Charles J Godfray and Austin Burt},
  booktitle={Genetics},
  year={2017}
}
There is a need for new interventions against the ongoing burden of vector-borne diseases such as malaria and dengue. One suggestion has been to develop genes encoding effector molecules that block parasite development within the vector, and then use the nuclease-based homing reaction as a form of gene drive to spread those genes through target populations. If the effector gene reduces the fitness of the mosquito and does not contribute to the drive, then loss-of-function mutations in the… CONTINUE READING
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