Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

@article{Cox1997RequirementsFB,
  title={Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes },
  author={Dianne Cox and Peter Wg Chang and Qing Zhang and Prasad G Reddy and Gary M. Bokoch and Steven A. Greenberg},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={1487 - 1494}
}
Specific pathways linking heterotrimeric G proteins and Fcgamma receptors to the actin-based cytoskeleton are poorly understood. To test a requirement for Rho family members in cytoskeletal events mediated by structurally diverse receptors in leukocytes, we transfected the full-length human chemotactic peptide receptor in RAW 264.7 cells and examined cytoskeletal alterations in response to the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (FMLP), colony stimulating factor-1 (CSF-1… CONTINUE READING

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