Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

  title={Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base},
  author={Lucy Skrabanek and Marta Murcia and Michel Bouvier and Lakshmi Devi and Susan R. George and Martin J. Lohse and Graeme Milligan and Richard R. Neubig and Krzysztof Palczewski and Marc Parmentier and Jean-Philippe Pin and Gert Vriend and Jonathan A. Javitch and Fabien Campagne and Marta Filizola},
  journal={BMC Bioinformatics},
  pages={177 - 177}
G Protein-Coupled Receptors (GPCRs) are a large and diverse family of membrane proteins whose members participate in the regulation of most cellular and physiological processes and therefore represent key pharmacological targets. Although several bioinformatics resources support research on GPCRs, most of these have been designed based on the traditional assumption that monomeric GPCRs constitute the functional receptor unit. The increase in the frequency and number of reports about GPCR… CONTINUE READING


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