Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax

Abstract

Mitochondrial membrane permeabilization is central to apoptotic signaling and is directly regulated by the Bcl-2 family of proteins, consisting of anti-apoptotic members and pro-apoptotic members, although the precise mechanisms involved remain elusive. When cells are deficient in both pro-apoptotic multidomain members of this family (Bax and Bak… (More)
DOI: 10.1038/onc.2010.98

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