Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart.

@article{Brown1999RequirementOT,
  title={Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart.},
  author={Christopher S. B. Brown and Amanda Boyer and Raymond B Runyan and Joey V. Barnett},
  journal={Science},
  year={1999},
  volume={283 5410},
  pages={2080-2}
}
Transforming growth factor-beta (TGF-beta) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) lacks a recognizable signaling domain and has no clearly defined role in TGF-beta signaling. Cardiac endothelial cells that undergo epithelial-mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in… CONTINUE READING

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