Requirement of topoisomerase IV parC and parE genes for cell cycle progression and developmental regulation in Caulobacter crescentus.

@article{Ward1997RequirementOT,
  title={Requirement of topoisomerase IV parC and parE genes for cell cycle progression and developmental regulation in Caulobacter crescentus.},
  author={Dr. Carol V. Ward and A. Jamila. Newton},
  journal={Molecular microbiology},
  year={1997},
  volume={26 5},
  pages={897-910}
}
We have identified the parC and parE genes encoding DNA topoisomerase IV (Topo IV) in Caulobacter crescentus. We have also characterized the effect of conditional Topo IV mutations on cell division and morphology. Topo IV mutants of C. crescentus are unlike mutants of Escherichia coli and S. typhimurium, which form long filamentous cells that are defective in nucleoid segregation and divide frequently to produce anucleate cells. Topo IV mutants of C. crescentus are highly pinched at multiple… CONTINUE READING

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