Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.

@article{PrezVictoria2008RequirementOT,
  title={Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.},
  author={Francisco J P{\'e}rez-Victoria and Gonzalo A Mardones and Juan S Bonifacino},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 6},
  pages={
          2350-62
        }
}
The biosynthetic sorting of acid hydrolases to lysosomes relies on transmembrane, mannose 6-phosphate receptors (MPRs) that cycle between the TGN and endosomes. Herein we report that maintenance of this cycling requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex. Depletion of any of the three GARP subunits, Vps52, Vps53, or Vps54, by RNAi impairs sorting of the precursor of the acid hydrolase, cathepsin D, to lysosomes and leads to its secretion into the… CONTINUE READING
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