Requirement of the caspase-3/CPP32 protease cascade for apoptotic death following cytokine deprivation in hematopoietic cells.

@article{Ohta1997RequirementOT,
  title={Requirement of the caspase-3/CPP32 protease cascade for apoptotic death following cytokine deprivation in hematopoietic cells.},
  author={Tomohiko Ohta and Takeshi Kinoshita and Mariko Fujimoto Naito and Takenori Nozaki and Mitsuko Masutani and Takashi Tsuruo and Atsushi Miyajima},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 37},
  pages={23111-6}
}
Hematopoietic cytokines transduce cell survival signals, which are distinct from the signals necessary for the stimulation of DNA synthesis. Recently, the Ras and phosphatidylinositol 3-kinase pathways have been shown to play important roles in preventing apoptosis in various cell types, e.g. hematopoietic cells and neuronal cells. Withdrawal of cytokine(s), in turn, results in rapid inactivation of these survival pathways and eventually leads to cell death accompanied by the hallmarks of… CONTINUE READING

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