Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis.

@article{Wang2000RequirementOT,
  title={Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis.},
  author={Qingde Wang and Jaspal Singh Khillan and Paul Gadue and Kazuko Nishikura},
  journal={Science},
  year={2000},
  volume={290 5497},
  pages={
          1765-8
        }
}
The members of the ADAR (adenosine deaminase acting on RNA) gene family are involved in site-selective RNA editing that changes adenosine residues of target substrate RNAs to inosine. Analysis of staged chimeric mouse embryos with a high contribution from embryonic stem cells with a functional null allele for ADAR1 revealed a heterozygous embryonic-lethal phenotype. Most ADAR1+/- chimeric embryos died before embryonic day 14 with defects in the hematopoietic system. Our results suggest the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 182 CITATIONS, ESTIMATED 61% COVERAGE

Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair.

  • The European journal of neuroscience
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Serotonin 2c receptor RNA editing in major depression and suicide.

  • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2013
VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis

  • Journal of Molecular Medicine
  • 2004
VIEW 9 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2001
2019

CITATION STATISTICS

  • 11 Highly Influenced Citations

  • Averaged 9 Citations per year from 2017 through 2019