Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals.

@article{Anand2001RequirementOT,
  title={Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals.},
  author={Mridula Anand and Jason Rush and Sreerupa Ray and M A Doucey and Juergen Weik and F E Ware and Jan Hofsteenge and Charles J. Waechter and Mark A. Lehrman},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 2},
  pages={
          487-501
        }
}
The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively. The hamster Lec35 gene is shown to encode the previously… CONTINUE READING