Requirement of the IL-2 receptor beta chain for the development of Vgamma3 dendritic epidermal T cells.

@article{Kawai1998RequirementOT,
  title={Requirement of the IL-2 receptor beta chain for the development of Vgamma3 dendritic epidermal T cells.},
  author={Kenji Kawai and Hiroyuki Suzuki and Katschiro Tomiyama and Masahiro Minagawa and Tak W Mak and Pamela S Ohashi},
  journal={The Journal of investigative dermatology},
  year={1998},
  volume={110 6},
  pages={961-5}
}
Vgamma3 TCR cells develop in the fetal thymus and migrate to the skin as dendritic epidermal T cells (DETC). Fetal Vgamma3 thymocytes differentiate from immature heat stable antigen (HSA)high cells to mature HSAlow cells and the latter subset predominantly expresses IL-2 receptor beta chain (IL-2Rbeta). In this study, the role of IL-2Rbeta in the development of Vgamma3 cells was determined in IL-2Rbeta-deficient mice. There was a moderate reduction of mature HSAlow Vgamma3 thymocytes in IL… CONTINUE READING

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