Requirement of species-specific interactions for the activation of human gamma delta T cells by pamidronate.

@article{Kato2003RequirementOS,
  title={Requirement of species-specific interactions for the activation of human gamma delta T cells by pamidronate.},
  author={Yu Kato and Yoshimasa Tanaka and Hidenori Tanaka and Seiji Yamashita and Nagahiro Minato},
  journal={Journal of immunology},
  year={2003},
  volume={170 7},
  pages={3608-13}
}
Human gammadelta T cells bearing Vgamma2Vdelta2-TCR recognize various kinds of small nonpeptide Ags, and activation of them by a nitrogen-containing bisphosphonate Ag, pamidronate, requires Ag presentation by cells other than gammadelta T cells, including many human tumor cells. Present results demonstrated that tumor cell lines of nonhuman origins pulsed with pamidronate failed to activate human gammadelta T cells without exception, whereas most if not all human tumor cell lines could do so… CONTINUE READING
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