Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

@article{Boyce1992RequirementOP,
  title={Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.},
  author={Brendan F. Boyce and Toshiyuki Yoneda and Chrishanthi Lowe and Philippe Soriano and Gregory R. Mundy},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 4},
  pages={
          1622-7
        }
}
Targeted disruption of the c-src proto-oncogene in mice has shown that src expression is required for normal bone resorption, since the src-deficient mutants develop osteopetrosis. To evaluate the mechanisms by which src-deficiency affects osteoclast function, we treated src-deficient mice with the stimulants of bone resorption, IL-1, parathyroid hormone, and parathyroid hormone-related protein, and analyzed the effects by quantitative bone histomorphometry and electron microscopy. Increased… CONTINUE READING
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