Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction.

@article{Fukami2001RequirementOP,
  title={Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction.},
  author={Kiyoko Fukami and Kazuki Nakao and Takanari Inoue and Yasufumi Kataoka and Manabu Kurokawa and Rafael A. Fissore and Kyoko Nakamura and Motoya Katsuki and Katsuhiko Mikoshiba and Nobuaki Yoshida and Tadaomi Takenawa},
  journal={Science},
  year={2001},
  volume={292 5518},
  pages={920-3}
}
Several phospholipase C (PLC) isoforms have been found in male and female mammalian gametes, and splicing isoforms of PLCdelta4 are predominantly expressed in testis. Here we report that male mice in which the PLCdelta4 gene had been disrupted either produced few small litters or were sterile. In vitro fertilization studies showed that insemination with PLCdelta4-/- sperm resulted in significantly fewer eggs becoming activated and that the calcium transients associated with fertilization were… CONTINUE READING

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