Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function.

  title={Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function.},
  author={Kiyoko Fukami and Kiyoshi Furuhashi and Masaki Inagaki and Takeshi Endo and Sadashi Hatano and Tadaomi Takenawa},
  volume={359 6391},
Inositol phospholipid turnover is enhanced during mitogenic stimulation of cells by growth factors and the breakdown of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) may be important in triggering cell proliferation. PtdInsP2 also binds actin-binding proteins to regulate their activity, but it is not yet understood how this control is achieved. The protein alpha-actinin from striated muscle contains large amounts of endogenous PtdInsP2, whereas that from smooth muscle has only a little but… CONTINUE READING