Requirement of phosphatidylinositol-3 kinase for epithelial cell migration activated by human macrophage stimulating protein.

@article{Wang1996RequirementOP,
  title={Requirement of phosphatidylinositol-3 kinase for epithelial cell migration activated by human macrophage stimulating protein.},
  author={Mingyi Wang and F{\'e}lix A. Montero-Julian and I Dauny and Edward J. Leonard},
  journal={Oncogene},
  year={1996},
  volume={13 10},
  pages={2167-75}
}
Macrophage stimulating protein (MSP) is a ligand for the RON receptor protein tyrosine kinase. Activation of RON in murine resident macrophages results in cell shape change and migration. We studied cell movement induced by MSP in different types of human epithelial cells and the possible role of phosphatidylinositol-3 (PI-3) kinase in RON-mediated signal transduction. We observed specific and saturable binding of 125I-MSP to RON on several epithelial cell lines. In addition to activation and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Scatter Factors in renal disease: Dr. Jeckyll and Mr. Hyde?

Cytokine & growth factor reviews • 2009
View 6 Excerpts
Highly Influenced

The modulation of macrophage activation by tyrosine phosphorylation.

Frontiers in bioscience : a journal and virtual library • 2002
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…