Requirement of new protein synthesis of a transcription factor for memory consolidation: paradoxical changes in mRNA and protein levels of C/EBP.

@article{Hatakeyama2006RequirementON,
  title={Requirement of new protein synthesis of a transcription factor for memory consolidation: paradoxical changes in mRNA and protein levels of C/EBP.},
  author={Dai Hatakeyama and Hisayo Sadamoto and Takayuki Watanabe and Akiko Wagatsuma and Suguru Kobayashi and Yutaka Fujito and Masakane Yamashita and Manabu Sakakibara and Gy{\"o}rgy Kemenes and Etsuro Ito},
  journal={Journal of molecular biology},
  year={2006},
  volume={356 3},
  pages={569-77}
}
Some specific transcription factors are essential for memory consolidation across species. However, it is still unclear whether only the activation of constitutively expressed forms of these conserved transcription factors is involved in memory consolidation or their de novo synthesis also occurs after learning. This question has remained unanswered partly because of the lack of an efficient method for the determination of copy numbers of particular mRNAs in single neurons, which allows the… CONTINUE READING