Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system.

@article{Kawasaki2002RequirementON,
  title={Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system.},
  author={Takahiko Kawasaki and Yoko Bekku and Fumikazu Suto and Takashi Kitsukawa and Masahiko Taniguchi and Ikuko Nagatsu and Toshiharu Toshi Nagatsu and Kazuo Itoh and Takeshi Yagi and Hajime Fujisawa},
  journal={Development},
  year={2002},
  volume={129 3},
  pages={671-80}
}
Neuropilin 1 is the specific receptor for Sema3A and plays a role in nerve fiber guidance. We report that neuropilin 1 and Sema3A mutant mouse embryos, generated by targeted gene disruption, showed displacement of sympathetic neurons and their precursors and abnormal morphogenesis in the sympathetic trunk. We also show that Sema3A suppressed the cell migration activity of sympathetic neurons from wild-type but not neuropilin 1 mutant embryos in vitro and instead promoted their accumulation into… CONTINUE READING

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