Requirement of myeloid cells for axon regeneration.

@article{Barrette2008RequirementOM,
  title={Requirement of myeloid cells for axon regeneration.},
  author={Benoit Barrette and Marc-Andr{\'e} H{\'e}bert and M. Maskani Filali and Kathleen Lafortune and Nicolas Valli{\`e}res and Genevieve Gowing and Jean-Pierre Julien and Steve Lacroix},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 38},
  pages={9363-76}
}
The role of CD11b+ myeloid cells in axonal regeneration was assessed using axonal injury models and CD11b-TK(mt-30) mice expressing a mutated HSV-1 thymidine kinase (TK) gene regulated by the myeloid-specific CD11b promoter. Continuous delivery of ganciclovir at a sciatic nerve lesion site greatly decreased the number of granulocytes/inflammatory monocytes and macrophages in the distal stump of CD11b-TK(mt-30) mice. Axonal regeneration and locomotor function recovery were severely compromised… CONTINUE READING

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