Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH.

@article{Piao2001RequirementOM,
  title={Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH.},
  author={Hailan Piao and Ningren Cui and Huimin Xu and Jian Chang Mao and Asheebo Rojas and Rong Wang and L. Abdulkadir and Lin-Sheng Li and Jianping Wu and Chun Jiang},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 39},
  pages={36673-80}
}
ATP-sensitive K(+) channels (K(ATP)) are regulated by pH in addition to ATP, ADP, and phospholipids. In the study we found evidence for the molecular basis of gating the cloned K(ATP) by intracellular protons. Systematic constructions of chimerical Kir6.2-Kir1.1 channels indicated that full pH sensitivity required the N terminus, C terminus, and M2 region. Three amino acid residues were identified in these protein domains, which are Thr-71 in the N terminus, Cys-166 in the M2 region, and His… CONTINUE READING

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