Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state

@article{Denis1988RequirementOH,
  title={Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state},
  author={Marc Denis and Lorenz Poellinger and Ann-Charlotte Wikst{\"o}m and Jan-Aˇke Gustafsson},
  journal={Nature},
  year={1988},
  volume={333},
  pages={686-688}
}
A central question arising from the model of eukaryotic gene regulation by steroid hormone receptors is whether or not proteins represent pre-existing gene regulatory proteins that are activated on exposure to the extracellular signal. It has been generally believed that the ligand-binding of steroid hormone receptors triggers an allosteric change in receptor structure, manifested by an increased affinity of the receptor for DNA in vitro and nuclear target elements in vivo, as monitored by… CONTINUE READING

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