Requirement of histone deacetylase activity for the expression of critical photoreceptor genes

@article{Chen2006RequirementOH,
  title={Requirement of histone deacetylase activity for the expression of critical photoreceptor genes},
  author={Bo Chen and Constance L. Cepko},
  journal={BMC Developmental Biology},
  year={2006},
  volume={7},
  pages={78 - 78}
}
BackgroundHistone deacetylases (HDACs) play a major role in the regulation of gene transcription, often leading to transcriptional repression, as well as other effects following deacetylation of non-histone proteins.ResultsTo investigate the role of HDACs in the developing mammalian retina, a general inhibitor of HDACs, trichostatin-A (TSA), was used to treat newborn murine retinae in explant cultures. Inhibition of HDAC activity resulted in a reduction in RNA levels for genes that regulate… CONTINUE READING

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