Requirement of central ghrelin signaling for alcohol reward.

  title={Requirement of central ghrelin signaling for alcohol reward.},
  author={Elisabet Jerlhag and Emil Egecioglu and Sara Landgren and Nicolas Salom{\'e} and Markus Heilig and Diederik W. Moechars and R. P. Datta and Daniel Perrissoud and Suzanne L Dickson and J{\"o}rgen A. Engel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 27},
The stomach-derived hormone ghrelin interacts with key CNS circuits regulating energy balance and body weight. Here we provide evidence that the central ghrelin signaling system is required for alcohol reward. Central ghrelin administration (to brain ventricles or to tegmental areas involved in reward) increased alcohol intake in a 2-bottle (alcohol/water) free choice limited access paradigm in mice. By contrast, central or peripheral administration of ghrelin receptor (GHS-R1A) antagonists… CONTINUE READING


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Association of pro-ghrelin and GHS-R1A gene polymorphisms and haplotypes with heavy alcohol use and body mass

  • S Landgren
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