Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis.

@article{Lidonnici2008RequirementOC,
  title={Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis.},
  author={Maria Rosa Lidonnici and Francesca Corradini and Todd J. Waldron and Timothy Bender and Bruno Calabretta},
  journal={Blood},
  year={2008},
  volume={111 9},
  pages={4771-9}
}
The c-Myb gene encodes a transcription factor required for proliferation and survival of normal myeloid progenitors and leukemic blast cells. Targeting of c-Myb by antisense oligodeoxynucleotides has suggested that myeloid leukemia blasts (including chronic myelogenous leukemia [CML]-blast crisis cells) rely on c-Myb expression more than normal progenitors, but a genetic approach to assess the requirement of c-Myb by p210(BCR/ABL)-transformed hematopoietic progenitors has not been taken. We… CONTINUE READING
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