Requirement of a Stable Secondary Structure for the Antiviral Activity of Polynucleotides

@article{Clercq1969RequirementOA,
  title={Requirement of a Stable Secondary Structure for the Antiviral Activity of Polynucleotides},
  author={Erik De Clercq and Thomas C. Merigan},
  journal={Nature},
  year={1969},
  volume={222},
  pages={1148-1152}
}
Several polyribonucleotides, both as single species and when annealed in pairs, are able to induce interferon production in mammalian cells and cellular resistance to virus infection. These studies suggest that a stable secondary, presumably multistranded structure is required for this activity. 
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