Requirement of a GT box (Sp1 site) and two Ets binding sites for vascular endothelial cadherin gene transcription.

@article{Gory1998RequirementOA,
  title={Requirement of a GT box (Sp1 site) and two Ets binding sites for vascular endothelial cadherin gene transcription.},
  author={S Gory and Jacques Dalmon and Marie H{\'e}l{\`e}ne Prandini and Thierry Kortulewski and Yvan de Launoit and Philippe Huber},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 12},
  pages={6750-5}
}
Vascular endothelial cadherin (VE cadherin) gene encodes a Ca2+-dependent cell adhesion molecule required for the organization of interendothelial junctions. This gene is exclusively and constitutively expressed in endothelial cells. Previous data with transgenic mice revealed that the transcriptional regulatory elements present within a -2486/+24 DNA fragment of mouse VE cadherin gene mimic the tissue-specific activity of the endogenous promoter. In this study, we analyzed elements implicated… CONTINUE READING

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