Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm.

@article{Kishi2000RequirementOS,
  title={Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm.},
  author={Masashi Kishi and K Mizuseki and Noriaki Sasai and Hidetoshi Yamazaki and Kohei Shiota and Shigetada Nakanishi and Yoshiki Sasai},
  journal={Development},
  year={2000},
  volume={127 4},
  pages={791-800}
}
From early stages of development, Sox2-class transcription factors (Sox1, Sox2 and Sox3) are expressed in neural tissues and sensory epithelia. In this report, we show that Sox2 function is required for neural differentiation of early Xenopus ectoderm. Microinjection of dominant-negative forms of Sox2 (dnSox2) mRNA inhibits neural differentiation of animal caps caused by attenuation of BMP signals. Expression of dnSox2 in developing embryos suppresses expression of N-CAM and regional neural… CONTINUE READING
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