Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion.

@article{Liu2006RequirementOS,
  title={Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion.},
  author={Guangming Liu and Wei Ding and Jill M Neiman and Kathleen M. Mulder},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 40},
  pages={29479-90}
}
Because increased transforming growth factor-beta (TGFbeta) production by tumor cells contributes to cancer progression through paracrine mechanisms, identification of critical points that can be targeted to block TGFbeta production is important. Previous studies have identified the precise signaling components and promoter elements required for TGFbeta induction of TGFbeta1 expression in epithelial cells (Yue, J., and Mulder, K. M. (2000) J. Biol. Chem. 275, 30765-30773). To determine how… CONTINUE READING
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