Requirement of Retinoic Acid Receptor β for Genipin Derivative-Induced Optic Nerve Regeneration in Adult Rat Retina

@article{Koriyama2013RequirementOR,
  title={Requirement of Retinoic Acid Receptor $\beta$ for Genipin Derivative-Induced Optic Nerve Regeneration in Adult Rat Retina},
  author={Y. Koriyama and Yusuke Takagi and K. Chiba and M. Yamazaki and K. Sugitani and K. Arai and Hirokazu Suzuki and S. Kato},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
Like other CNS neurons, mature retinal ganglion cells (RGCs) are unable to regenerate their axons after nerve injury due to a diminished intrinsic regenerative capacity. One of the reasons why they lose the capacity for axon regeneration seems to be associated with a dramatic shift in RGCs’ program of gene expression by epigenetic modulation. We recently reported that (1R)-isoPropyloxygenipin (IPRG001), a genipin derivative, has both neuroprotective and neurite outgrowth activities in murine… Expand
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