Requirement of RNA and protein synthesis and inhibition by ethylenediaminetetraacetic acid of retinoic acid-induced proteoglycan release in a transplantable rat chondrosarcoma.

@article{Kistler1980RequirementOR,
  title={Requirement of RNA and protein synthesis and inhibition by ethylenediaminetetraacetic acid of retinoic acid-induced proteoglycan release in a transplantable rat chondrosarcoma.},
  author={Andreas David Kistler and Hella Hartmann},
  journal={Journal of the National Cancer Institute},
  year={1980},
  volume={64 3},
  pages={525-30}
}
In in vitro cultures of prepared pieces of transplantable chondrosarcoma from F344 rats, retinoic acid enhanced the release of proteoglycan, with a lag between 6 and 14 hours. The retinoic acid-induced release of proteoglycan was inhibited in vivo and in vitro by cycloheximide, an inhibitor of protein synthesis, and in vitro by actinomycin D and cordycepin, inhibitors of RNA synthesis. These results suggested that the retinoic acid-induced release of proteoglycan depends on de novo RNA and… CONTINUE READING