Requirement of Pygopus 2 in breast cancer.

  title={Requirement of Pygopus 2 in breast cancer.},
  author={Phillip G P Andrews and Blue B. Lake and Catherine Popadiuk and Kenneth R. Kao},
  journal={International journal of oncology},
  volume={30 2},
The development of novel therapeutic strategies for breast cancer requires the identification of molecular targets involved in malignancy. Human Pygopus (Pygo)-1 and -2 are recently discovered components of the Wnt signaling pathway required for beta-Catenin/Tcf dependent transcription in embryos and colorectal cancer cells, but the role of these proteins in malignant cell growth and survival has not yet been determined. We report the expression and requirement for proliferation of hPygo2 in… CONTINUE READING