Requirement of Prefrontal and Midbrain Regions for Rapid Executive Control of Behavior in the Rat

@article{Duan2015RequirementOP,
  title={Requirement of Prefrontal and Midbrain Regions for Rapid Executive Control of Behavior in the Rat},
  author={Chunyu A Duan and Jeffrey C. Erlich and Carlos D. Brody},
  journal={Neuron},
  year={2015},
  volume={86},
  pages={1491-1503}
}
To study rapid sensorimotor remapping, we developed a method to train rats in a behavior in which subjects are cued, on each trial, to apply a sensorimotor association to orient either toward a visual target ("Pro") or away from it, toward its reverse ("Anti"). Multiple behavioral asymmetries suggested that Anti behavior is cognitively demanding while Pro is easier to learn and perform. This is consistent with a prominent hypothesis in the primate literature that Anti requires prefrontal cortex… CONTINUE READING
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