Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis.

@article{Lubberts2005RequirementOI,
  title={Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis.},
  author={Erik Lubberts and Paul O. Schwarzenberger and Weitao Huang and Jill R. Schurr and Jacques J. Peschon and Wim B. van den Berg and Jay K Kolls},
  journal={Journal of immunology},
  year={2005},
  volume={175 5},
  pages={3360-8}
}
IL-17 is a proinflammatory cytokine suspected to be involved in inflammatory and autoimmune diseases such as rheumatoid arthritis. In the present study, we report that IL-17R signaling is required in radiation-resistant cells in the joint for full progression of chronic synovitis and bone erosion. Repeated injections of Gram-positive bacterial cell wall fragments (streptococcal cell wall) directly into the knee joint of naive IL-17R-deficient (IL-17R-/-) mice had no effect on the acute phase of… CONTINUE READING

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