Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation.

@article{Fujiuchi2004RequirementOI,
  title={Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation.},
  author={Nobuko Fujiuchi and Jason A Aglipay and Takao Ohtsuka and Naoki Maehara and F Pinar Sahin and Gloria H. Su and Sam W. Lee and Toru 3 Ouchi},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 19},
  pages={20339-44}
}
IFI16 is a member of the PYRIN superfamily that has been implicated in BRCA1-mediated apoptosis and inflammation signaling pathways. Here we report that most breast cancer cell lines examined expressed decreased mRNA and protein levels of IFI16, although IFI16 is expressed in human primary normal mammary epithelial cells. Significantly, immunohistochemical analysis of tissues from 25 breast cancer patients demonstrated that carcinoma cells showed negative or weaker staining of IFI16 compared… CONTINUE READING

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