Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

@article{Santarelli2003RequirementOH,
  title={Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants},
  author={L. Santarelli and M. Saxe and C. Gross and A. Surget and F. Battaglia and S. Dulawa and N. Weisstaub and J. Lee and R. Duman and O. Arancio and C. Belzung and R. Hen},
  journal={Science},
  year={2003},
  volume={301},
  pages={805 - 809}
}
  • L. Santarelli, M. Saxe, +9 authors R. Hen
  • Published 2003
  • Medicine
  • Science
  • Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse… CONTINUE READING

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