Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

@article{Santarelli2003RequirementOH,
  title={Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants},
  author={Luca Santarelli and Michael D. Saxe and Cornelius Thilo Gross and Alexandre Surget and Fortunato Battaglia and Stephanie C. Dulawa and Noelia V. Weisstaub and James J. Lee and Ronald Duman and Ottavio Arancio and Catherine Belzung and Ren{\'e} Hen},
  journal={Science},
  year={2003},
  volume={301},
  pages={805 - 809}
}
Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse… 
Adult hippocampal neurogenesis and antidepressants effects.
TLDR
The effects of stress and antidepressant treatments on adult-born neurons, and subsequently, the role and mechanisms of neurogenesis in antidepressant action are discussed.
Adult hippocampal neurogenesis and antidepressants effects.
TLDR
The effects of stress and antidepressant treatments on adult neurogenesis are discussed, and subsequently, the functional roles of adult-born neurons and the mechanisms underlying their antidepressant action are discussed.
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The hippocampus of patients with depression show signs of atrophy and neuronal loss, which suggests that adult neurogenesis may contribute to the biology of depression.
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This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients.
Genetic Regulation of Behavioral and Neuronal Responses to Fluoxetine
TLDR
It is shown that there is a genetic component to both the behavioral and neuronal effects of chronic fluoxetine treatment, and that this antidepressant induces an increase in hippocampal cell proliferation only in the strains that also show a positive behavioral response to treatment.
Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy
TLDR
Experimental and clinical data demonstrating that stress and antidepressant treatments affect neurogenesis in opposite direction in rodents supports the view that neuroplastic phenomena are involved in the physiopathology of depression and underlie—at least partly—antidepressant therapy.
Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression
TLDR
A mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment is described, and mice deficient in one of these genes, beta-arrestin 2, displayed a reduced response to fluoxetine in multiple tasks, suggesting that beta-Arrestin signaling is necessary for the antidepressant effects of fluoxettine.
Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment
TLDR
The literature that has lead to a neurogenic hypothesis of depression and antidepressant action, as well as the molecular and cellular mechanisms that underlie the regulation of adult neurogenesis by stress and antidepressant treatment are discussed.
Neurotrophic effects of antidepressant drugs.
  • E. Castrén
  • Psychology, Medicine
    Current opinion in pharmacology
  • 2004
TLDR
Data suggest that antidepressants facilitate activity-dependent selection of functional synaptic connections in brain and, through their neurotrophic effects, improve information processing within neuronal networks compromised in mood disorders.
Adult hippocampal neurogenesis in depression
TLDR
The functional differentiation of the hippocampus along the septo-temporal axis is revisited and it is suggested that neurogenesis in the ventral dentate gyrus may be preferentially involved in regulation of emotion.
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