Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition.

@article{Shan2008RequirementOH,
  title={Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition.},
  author={Bin Shan and Tso-pang Yao and Hong Kong T. Nguyen and Ying Zhuo and Dawn R. Levy and Ross C. Klingsberg and Hui Tao and Michael L Palmer and Kevin N. Holder and Joseph A. Lasky},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 30},
  pages={21065-73}
}
The aberrant expression of transforming growth factor (TGF)-beta1 in the tumor microenvironment and fibrotic lesions plays a critical role in tumor progression and tissue fibrosis by inducing epithelial-mesenchymal transition (EMT). EMT promotes tumor cell motility and invasiveness. How EMT affects motility and invasion is not well understood. Here we report that HDAC6 is a novel modulator of TGF-beta1-induced EMT. HDAC6 is a microtubule-associated deacetylase that predominantly deacetylates… CONTINUE READING

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