Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor.

@article{Connolly1991RequirementOG,
  title={Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor.},
  author={Timothy Connolly and Peter J Rapiejko and Reid Gilmore},
  journal={Science},
  year={1991},
  volume={252 5009},
  pages={1171-3}
}
The signal recognition particle (SRP) directs signal sequence specific targeting of ribosomes to the rough endoplasmic reticulum. Displacement of the SRP from the signal sequence of a nascent polypeptide is a guanosine triphosphate (GTP)-dependent reaction mediated by the membrane-bound SRP receptor. A nonhydrolyzable GTP analog can replace GTP in the signal sequence displacement reaction, but the SRP then fails to dissociate from the membrane. Complexes of the SRP with its receptor containing… CONTINUE READING
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