Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice

  title={Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice },
  author={Naoto Itoh and Akihisa Imagawa and Toshiaki Hanafusa and Masako Waguri and Koji Yamamoto and Hiromi Iwahashi and Makoto Moriwaki and Hiromu Nakajima and Junichiro Miyagawa and Mitsuyoshi Namba and Susumu Makino and Shigekazu Nagata and Norio Kono and Yuji Matsuzawa},
  journal={The Journal of Experimental Medicine},
  pages={613 - 618}
Insulin-dependent diabetes mellitus (IDDM) is assumed to be a T cell-mediated autoimmune disease. To investigate the role of Fas-mediated cytotoxicity in pancreatic beta cell destruction, we established nonobese diabetic (NOD)-lymphoproliferation (lpr)/lpr mice lacking Fas. Out of three genotypes, female NOD-+/+ and NOD-+/lpr developed spontaneous diabetes by the age of 10 mo with the incidence of 68 and 62%, respectively. In contrast, NOD-lpr/lpr did not develop diabetes or insulitis. To… CONTINUE READING


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