Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice

@article{Itoh1997RequirementOF,
  title={Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice },
  author={Naoto Itoh and Akihisa Imagawa and Toshiaki Hanafusa and Masako Waguri and Koji Yamamoto and Hiromi Iwahashi and Makoto Moriwaki and Hiromu Nakajima and Junichiro Miyagawa and Mitsuyoshi Namba and Susumu Makino and Shigekazu Nagata and Norio Kono and Yuji Matsuzawa},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={613 - 618}
}
Insulin-dependent diabetes mellitus (IDDM) is assumed to be a T cell-mediated autoimmune disease. To investigate the role of Fas-mediated cytotoxicity in pancreatic beta cell destruction, we established nonobese diabetic (NOD)-lymphoproliferation (lpr)/lpr mice lacking Fas. Out of three genotypes, female NOD-+/+ and NOD-+/lpr developed spontaneous diabetes by the age of 10 mo with the incidence of 68 and 62%, respectively. In contrast, NOD-lpr/lpr did not develop diabetes or insulitis. To… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 98 extracted citations

Deletion of Fas in the pancreatic beta-cells leads to enhanced insulin secretion.

American journal of physiology. Endocrinology and metabolism • 2009
View 4 Excerpts
Highly Influenced

- Cell Apoptosis Stimuli and Signaling

Thomas Mandrup-Poulsen Pancreatic
2001
View 7 Excerpts
Highly Influenced

Significant role for Fas in the pathogenesis of autoimmune diabetes.

Journal of immunology • 2000
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Mouse islet cell lysis mediated by interleukin-1-induced Fas

Diabetologia • 1996
View 5 Excerpts
Highly Influenced

Fas ligand in human serum

Nature Medicine • 1996
View 1 Excerpt

Similar Papers

Loading similar papers…