Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase.

@article{Wiegmann1999RequirementOF,
  title={Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase.},
  author={Katja Wiegmann and Ralf T. Schwandner and Oleg Krut and W. C. Yeh and Tak W Mak and M D Kurt Kroenke},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 9},
  pages={5267-70}
}
The generation of mice strains deficient for select members of the signaling complex of the 55-kDa tumor necrosis factor receptor (TNF-R55) has allowed the assignment of specific cellular responses to distinct TNF-R55-associated proteins. In particular, the TNF-R55-associated protein FADD seems to be responsible for recruitment and subsequent activation of caspase 8. In this report we demonstrate the requirement of FADD for TNF-induced activation of endosomal acid sphingomyelinase (A-SMase). In… CONTINUE READING
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