Requirement of ERK Activation for Visual Cortical Plasticity

@article{Cristo2001RequirementOE,
  title={Requirement of ERK Activation for Visual Cortical Plasticity},
  author={Graziella di Cristo and Nicoletta Berardi and Laura Cancedda and Tommaso Pizzorusso and Elena Putignano and Gian Michele Ratto and Lamberto Maffei},
  journal={Science},
  year={2001},
  volume={292},
  pages={2337 - 2340}
}
Experience-dependent plasticity in the developing visual cortex depends on electrical activity and molecular signals involved in stabilization or removal of inputs. Extracellular signal–regulated kinase 1,2 (also called p42/44 mitogen-activated protein kinase) activation in the cortex is regulated by both factors. We show that two different inhibitors of the ERK pathway suppress the induction of two forms of long-term potentiation (LTP) in rat cortical slices and that their intracortical… 
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